Open AccessEffects of the Rho/Rho-Kinase Pathway on Perfusion Pressure in the Isolated-Perfused Rat Hind Limb Vascular Bed
Author(s) -
Esra İlhan,
Kansu Büyükafşar,
Rukiye Nalan Tiftik,
Mehmet Ata Seçilmiş,
Zayed Al-Zayed
Publication year - 2021
Publication title -
balkan medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.398
H-Index - 16
eISSN - 2146-3131
pISSN - 2146-3123
DOI - 10.5152/balkanmedj.2021.20014
Subject(s) - fasudil , rhoa , rho associated protein kinase , hindlimb , perfusion , vasodilation , medicine , vascular smooth muscle , chemistry , anatomy , pharmacology , biochemistry , kinase , signal transduction , smooth muscle
Rho/ROCK signaling has been demonstrated to be involved in the vascular reactivity of many arterial networks. However, RhoA expression and the contribution of Rho/ROCK pathway to the control of perfusion pressure have not been investigated in the rat hind limb vascular bed as a skeletal muscle vascular network.