Open AccessAquaporin-1 and Aquaporin-3 Expressions in the Intervertebral Disc of Rats with Aging
Author(s) -
Ufuk Taş,
Sevil Çaylı,
Ahmet İnanır,
Birsen Özyurt,
Seda Ocaklı,
Zafer İsmail Karaca,
Mustafa Sarsılmaz
Publication year - 2012
Publication title -
balkan medical journal/balkan medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.398
H-Index - 16
eISSN - 2146-3131
pISSN - 2146-3123
DOI - 10.5152/balkanmedj.2012.079
Subject(s) - intervertebral disc , aquaporin , immunohistochemistry , lumbar , pathology , degeneration (medical) , medicine , aquaporin 1 , aquaporin 4 , intervertebral disk , anatomy , water channel , physiology , mechanical engineering , engineering , inlet
The intervertebral disc (IVD) undergoes biochemical and morphologic degenerative changes during the process of aging. Aquaporins (AQPs) are a family of water channel proteins that facilitate water and small solute movement in tissues and may have a potential role in the aging degeneration of IVDs. One of the important problems in understanding disc degeneration is to find cellular molecules which contribute to the pathogenesis of IVDs. XThe aim of this study was to demonstrate the expression of aquaporin 1 and 3 in nucleus pulposus (NP), annulus fibrosus (AF) cells of rat lumbar intervertebral discs from both young and aged animals using immunohistochemistry.