Open AccessFORMULATION AND EVALUATION OF CARICA PAPAYA NANOEMULSION FOR TREATMENT OF DENGUE AND THROMBOCYTOPENIA
Author(s) -
Suraj Mandal,
V. P. Jaiswal,
Manoj Kumar Sagar,
S. Senthil Kumar
Publication year - 2021
Publication title -
plant archives/plant archives
Language(s) - English
Resource type - Journals
eISSN - 2581-6063
pISSN - 0972-5210
DOI - 10.51470/plantarchives.2021.v21.no1.179
Subject(s) - carica , pulmonary surfactant , polyethylene glycol , chromatography , particle size , solubility , emulsion , chemistry , materials science , botany , organic chemistry , biochemistry , biology
Aim of the current research work was to enhance availability of Carica papaya to through the oral route using nanoemulsion approach. The attempt was made to develop a nanoemulsion formulation of Carica papaya and its evaluation in the treatment of dengue as well as thrombocytopenia. Nanoemulsion is clear, heterogeneous emulsion (of droplet size 50-200 nm) consists of surfactant/co-surfactant (Smix), oil, water and drug. Different components were selected on the basis of solubility of Carica papaya in different oils. Tween 20 and polyethylene glycol (PEG-400) was selected as surfactant/co-surfactant, while oleic acid used as an oil phase in nanoemulsion. Nanoemulsion formulations are physically identified on the basis of phase diagram. These are characterized on the basis of viscosity, conductivity, refractive index morphological and stability evaluation etc. This combination of Smix and oil ratio had sufficient capacity to load Carica papaya leaf powder (drug) which yielded nano emulsification in aqueous media and produced nanoemulsion with droplet size (63.37nm).According to all evaluation parameters, formulation number-4 (F4) showed the promising prospective on the basis of particle size range