Open AccessEFFECT OF TETRAHYDROCURCUMIN ON LIPID PROFILES IN STREPTOZOTOCIN–NICOTINAMIDE INDUCED TYPE 2 DIABETES MELLITUS
Author(s) -
Pidaran Murugan
Publication year - 2021
Publication title -
plant archives/plant archives
Language(s) - English
Resource type - Journals
eISSN - 2581-6063
pISSN - 0972-5210
DOI - 10.51470/plantarchives.2021.v21.no1.168
Subject(s) - streptozotocin , hyperlipidemia , very low density lipoprotein , medicine , diabetes mellitus , low density lipoprotein , endocrinology , nicotinamide , oral administration , cholesterol , high density lipoprotein , lipoprotein , chemistry , biochemistry , enzyme
Hyperlipidemia is one of the major risk factors of cardiovascular complication in diabetes. A study was undertaken to evaluate the antihyperlipidemic activity of tetrahydrocurcumin (THC). Oral administration of THC (80mg/ kg bodyweight) to streptozotocin-nicotinamide induced diabetic rats for 45 days, significantly reduced the elevated serum very low density lipoprotein (VLDL) and low density lipoprotein (LDL) – cholesterol levels and significantly increased the serum high-density lipoprotein (HDL)-cholesterol. THC showed a better effect when compared with curcumin. Results of the present study indicate that THC showed antihyperlipidemic effect in addition to its antidiabetic effect in type 2 diabetic rats