Open AccessPrognosis of gastric adenocarcinoma associated with girdin, Akt, and cortactin
Author(s) -
Yue Zhang,
Cheyan Liu,
Lei Zhou
Publication year - 2022
Publication title -
annals of saudi medicine/annals of saudi medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.373
H-Index - 44
eISSN - 0975-4466
pISSN - 0256-4947
DOI - 10.5144/0256-4947.2022.181
Subject(s) - cortactin , protein kinase b , pi3k/akt/mtor pathway , cancer research , medicine , metastasis , actin cytoskeleton , signal transduction , cell , biology , microbiology and biotechnology , cytoskeleton , cancer , biochemistry
The actin-binding protein girdin regulates tumor cell migration and invasion by maintaining actin structure. PI3K/Akt signaling is an important actin-remodeling pathway. The protein cortactin acts directly on microfilaments and promotes tumor invasion and metastasis by rearranging the cytoskeleton. However, there are few reports on the co-expression of girdin, Akt, and cortactin in gastric adenocarcinoma (GAC).