Investigations on noval method for the formulation of solid dispersions part- I Formulation, characterization and selection | Zendy

Rakesh Kumar Sharma | Zendy; Anil Middha | Zendy

Open Access

Investigations on noval method for the formulation of solid dispersions part- I Formulation, characterization and selection

Author(s) -

Rakesh Kumar Sharma,

Anil Middha

Publication year - 2017

Publication title -

international journal of drug delivery

Language(s) - English

Resource type - Journals

ISSN - 0975-0215

DOI - 10.5138/09750215.2173

Subject(s) - dissolution , solubility , chromatography , polymer , dissolution testing , materials science , nuclear chemistry , chemistry , organic chemistry , biopharmaceutics classification system

The solid dispersions of indomethacin with hydrophilic polymers were prepared by lyophilization. The polymers used in the investigation were HPMC, PVP K30, CBR and PLF 127. The solubility and dissolution of indomethacin from prepared lyophilized solid dispersions were investigated in 0.1 N HCl, purified water and USP-NF dissolution media. Out of fifteen lyophilized formulations from F1 to F15, five formulations F2, F5, F8, F12 and F14 showed highest solubility in purified water. Formulation F2, F8 failed to comply with the USP-NF dissolution test for indomethacin capsules. Formulation F14 showed maximum dissolution in the respective dissolution media within 60 min. Sustained drug release was observed for 6 h with formulations F2 and F8 in USP-NF media. The formulations F2, F5, F8, F12 and F14 were characterized by modulated DSC and FT-IR spectroscopy. Some Formulations on stability testing were found physico-chemically stable at accelerated temperature conditions.

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