Open Accessrs10737680 polymorphism in complement factor H and neovascular age-related macular degeneration in Yogyakarta, Indonesia
Author(s) -
Talenta Sigalingging,
Ayudha Bahana Ilham Perdamaian,
Dewi Fathin Romdhoniyyah,
Muhammad Eko Prayogo,
Firman Setya Wardhana,
Tri Wahyu Widayanti,
Muhammad Bayu Sasongko,
Angela Nurini Agni,
Chio Oka,
Supanji Supanji
Publication year - 2022
Publication title -
medical hypothesis discovery and innovation in ophthalmology
Language(s) - English
Resource type - Journals
eISSN - 2322-4436
pISSN - 2322-3219
DOI - 10.51329/mehdiophthal1448
Subject(s) - macular degeneration , medicine , factor h , ophthalmology , genotype , choroidal neovascularization , drusen , abca4 , allele , fundus (uterus) , retinal pigment epithelium , retinal , genetics , biology , complement system , immunology , antibody , gene , phenotype
Neovascular age-related macular degeneration (nAMD) is one of the main causes of blindness in developed countries. Complement factor H (CFH) is one of the genes involved in the pathogenesis of nAMD. This study investigated the rs10737680 polymorphism in CFH and its conferred susceptibility to nAMD in Yogyakarta, Indonesia.