Open AccessSynthesis, structure and cytotoxic activity of trans-[PtCl2(EugH)(Caffeine)] and [PtCl(Eug)(Caffeine)] (EugH: eugenol) complexes
Author(s) -
Hang Truong Thuy,
Duyen Le Thi,
Chi Nguyen Thi Thanh
Publication year - 2021
Publication title -
xúc tác và hấp phụ
Language(s) - English
Resource type - Journals
ISSN - 0866-7411
DOI - 10.51316/jca.2021.031
Subject(s) - chemistry , double bond , stereochemistry , deprotonation , medicinal chemistry , organic chemistry , ion
Interaction between K[PtCl3(EugH)] (1) and [PtCl(Eug)]2 (2) with Caf afforded two new complexes, trans-[PtCl2(EugH)(Caf)] (3) and [PtCl(Eug)(Caf)] (4), respectively. The procedure to synthesize complex 2 was improved. The structures of two new complexes were characterized by elemental analyses, MS, IR, 1H NMR and NOESY spectroscopies. The result indicated that EugH coordinates with Pt(II) at ethylenic double bond of the allyl group in complex 3, but in complex 4 it is deprotonated and bound with Pt(II) at both the double bond and C5 of the benzene ring. The donor N of caffein is in trans-position in 3 and in cis-position in 4 with respect to the ethylenic double bond. In chloroform solvent, 4 exists in two forms 4a and 4b corresponding to the strong intermolecular hydrogen bond Cl3C-H…ClPt(II) and the strong halogen bond Cl2HC-Cl…Pt(II). The result of testing cytotoxicity of 3 and 4 against four human cancer cells KB, Lu, Hep-G2 and MCF7 showed that complex 3 exhibits good activities on the KB and Hep-G2 with IC50 values of 81,03 and 89,29 μg/mL, respectively.