Open AccessSAFETY AND EFFICACY OF STEM CELL THERAPY FOR TREATMENT SEVERE TRAUMATIC BRAIN INJURY
Author(s) -
Nguyen Viet Quang Hien,
Le Hoang Duy Minh,
Phan Thi Dieu Ngan,
Le Gia Vinh,
Nguyen Viet Quang,
Phan Thi Thuy Hoa,
Che Thi Cam Ha
Publication year - 2021
Publication title -
y học việt nam
Language(s) - English
Resource type - Journals
ISSN - 1859-1868
DOI - 10.51298/vmj.v506i1-2.990
Subject(s) - traumatic brain injury , medicine , mesenchymal stem cell , subclinical infection , quality of life (healthcare) , transplantation , adverse effect , stem cell , inflammation , surgery , pathology , nursing , psychiatry , biology , genetics
Traumatic brain injury (TBI) is a complicated topic.TBI has expensive treatment, sequelae, high mortality and efficient therapeutic strategies for TBI are urgently needed. Patients with severe TBI account for 10% of all traumatic brain injury patients, but more than 80% of patients who die from traumatic brain injury are in this group of patients. That proves the danger of severe TBI. Mesenchymal stem cells (MSCs) are multipotent cells with high proliferative and self-renewal capacities, as well as immunomodulatory and neuroregenerative effects. MSCshave been shown to treat TBI and significantly reduce inflammation of injured tissue. In the present study, we evaluated the quality and effectiveness of mesenchymal stem cell transplantation with the graft dose of 9x106cells/kg. Clinical indexes (Pulse, temperature, SBP, HATTr, HATTB, GCS) and subclinical (Hepatic index, kidney, cortisol, lactate, glucose, hematological index, respiratory index) were monitored on 60 patients within 6 months.
The results showed that the recovery journey is different for every person with the graft dose of 6-9x106 cells/kg, but there were no adverse complications for the patients, the clinical and paraclinical indicators were stable. No significant side effects were observed during the trial as well as after 6 months of treatment. The MSC transfusions significantly increased the life quality patients; reduced brain damage and increased HSC counts. Inflammatory cytokines (IL-6) levels decreased and GCS increased in the MSC transfusion group, indicating that the patient's health improved.