Open AccessEstudio comparativo entre el índice proteína/creatinina en una muestra de orina al azar y proteinuria en 24 horas como método diagnóstico de preeclampsia
Author(s) -
Nahiliu Gabriela Díaz Colina,
AUTHOR_ID,
Iralis Rosana Chiroque Parra,
J. I. Perez Garcia,
Noren Villalobos
Publication year - 2022
Publication title -
revista de obstetricia y ginecología de venezuela
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.11
H-Index - 8
ISSN - 0048-7732
DOI - 10.51288/00820108
Subject(s) - proteinuria , creatinine , receiver operating characteristic , medicine , preeclampsia , likelihood ratios in diagnostic testing , urology , urine , renal function , pregnancy , kidney , biology , genetics
Objective: To evaluate the usefulness of the Protein/Creatinine index (CPI) in a random urine sample, comparing it with 24-hour urine proteinuria, in patients with suspected pre-eclampsia. Methods: Cross-sectional study of a diagnostic test, random, comparative, observational, non-experimental, carried out between September 2018 - September 2019, at the Obstetrics and Gynecology Division of the Maracaibo University Hospital, Dr. Armando Castillo Plaza Maternity. 30 patients were selected. To determine the validity of the Protein/Creatinine index, the following were calculated: Sensitivity,Specificity, Positive Predictive Value, Negative Predictive Value, positive and the Receiver Operating Characteristic curve. The correlation between Protein/Creatinine index and 24-hour proteinuria was assessed using a two-way correlation plot and Spearman’s correlation coefficient. Results: The sensitivity of the Protein/Creatinine index was 90% and the specificity of 80%, with a Positive Predictive Value 90, and a Predictive Value negative 80, Positive Likelihood Ratio: 4,58, Negative Likelihood Ratio: 0.12. The Receiver Operating Characteristic curve indicated an area under the curve of 0.848, which means that there is an 84% probability that the Protein/Creatinine index was positive in proteinuria, with a cut-off point of 0.3. Conclusions: The Protein/Creatinine index is a reliable diagnostic tool that can easily be interpreted by trained health personnel, comparable to 24-hour proteinuria, with advantages such as saving time and easy interpretation. Keywords: Preeclampsia, Urine sample, Proteinuria, Creatinine.