Open AccessThe Effect of Vitamin D Administration on Androgen Levels in Addition to Metformin Treatment in Adolescent Girls with Hyperandrogenism
Author(s) -
Esranur Çiğ,
Müge Atar,
Özgür Pirgon
Publication year - 2022
Publication title -
the journal of pediatric academy.
Language(s) - English
Resource type - Journals
ISSN - 2718-0875
DOI - 10.51271/jpea-2022-162
Subject(s) - metformin , hyperandrogenism , medicine , endocrinology , androgen , vitamin , aspartate transaminase , testosterone (patch) , insulin , hormone , polycystic ovary , chemistry , insulin resistance , alkaline phosphatase , biochemistry , enzyme
This retrospective study was planned to examine the relationship between glucose metabolism, androgen and lipid profiles after vitamin D and metformin treatments in adolescent girls with hyperandrogenism. Forty-five adolescent female patients diagnosed with hyperandrogenism were divided into three groups. The first group of patients was given metformin (M), the second group was given metformin and vitamin D drops (MdD), and the third group were those who received oral metformin and vitamin D ampoules (MsD). Biochemical and hormonal parameters at the end of 8 weeks were compared statistically. The vitamin D level was higher in the metformin-vitamin D stoss treated group than metformin-vitamin D drops. There was a positive correlation between vitamin D and SHBG in the metformin group (r =0.65, p<0.01). A significant correlation was observed between triglyceride and insulin in both groups given vitamin D, and there was a decrease in these two values (p<0.05). There was a positive correlation between total testosterone and Alanine transaminase (ALT) in the MsD group (p<0.05). Additionally, a positive correlation was observed between SHBG and HDL-cholesterol in three groups. There was a significant correlation between androgen and lipid parameters in the 8-week metformin and vitamin D treated groups. Long-term studies using high-dose vitamin D are needed to support our results.