Open AccessThe importance of immature granulocyte and immature reticulocyte fraction for the severity of acute bronchiolitis
Author(s) -
Murat Doğan,
Mehmet Adnan Öztürk
Publication year - 2022
Publication title -
the journal of pediatric academy.
Language(s) - English
Resource type - Journals
ISSN - 2718-0875
DOI - 10.51271/jpea-2022-153
Subject(s) - medicine , eosinophil , receiver operating characteristic , white blood cell , gastroenterology , bronchiolitis , area under the curve , prospective cohort study , absolute neutrophil count , predictive value of tests , immunology , asthma , neutropenia , respiratory system , toxicity
The immature granulocyte (IG) and immature reticulocyte fraction (IRF) are new analytical parameters of the complete blood count, that have been studied as biomarkers of several inflammatory conditions. Here, our aim is to determine the effectiveness of IG and IRF percentages for the severity of acute bronchiolitis (AB). A single-center, prospective study was performed in patients who were hospitalized for acute bronchiolitis and healthy children were included as a control group. The demographic characteristics, white blood cell (WBC) count, platelet (PLT) count, eosinophil%, IG%, and IRF% values were analysed. Receiver operating characteristics (ROC) analysis was used to compare the diagnostic accuracies and predictive performances. We enrolled 168 infants in the acute bronchiolitis group and 80 in the control group. The Clinical Severity Score (CSS) showed that 48, 93, and 27 patients had mild, moderate, and severe bronchiolitis, respectively. The WBC, PLT, and IRF value were significantly higher in patients (p 12.4, with a sensitivity of 53% and specificity of 88% (Areas under the curves (AUC):0.701,p<0.001). The WBC count, PLT count, and IRF value increased in the AB group. The IRF percentage can be used to predict the clinical severity of AB in children.