Open AccessDRESS Sendromu: Bir Olgu Sunumu
Author(s) -
Cankat Doğantekin,
Havva Hilal Ayvaz,
İ̇jlal Erturan,
Gamze Erkılınç,
Selma Korkmaz,
Mehmet Yıldırım
Publication year - 2020
Publication title -
yüksek i̇htisas üniversitesi sağlık bilimleri dergisi :
Language(s) - English
Resource type - Journals
ISSN - 2717-9257
DOI - 10.51261/yiu.2020.00020
Subject(s) - blurred vision , rash , medicine , eosinophilia , carbamazepine , drug reaction , dermatology , leukopenia , drug , epilepsy , genetic predisposition , pediatrics , gastroenterology , surgery , psychiatry , toxicity , disease
DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) syndrome is a rare, life-threatening drug reaction characterized by acute onset of fever, skin rash, and multisystemic involvement. Although the pathophysiology is not exactly known, slow detoxification of arene oxide bioactive metabolites of drugs and viral coinfections are blamed in people with genetic predisposition. A 17-year-old male patient was admitted to our clinic with a rash covering his entire body for 5 days. The patient, who stated that he had been using carbamazepine for 4 months due to epilepsy, had fever reaching 38.5°C at the time of admission, impaired liver function tests, high CRP, leukopenia, thrombocytopenia and eosinophilia. The patient, who was hospitalized, developed sudden vision blurriness and the cranial MRI result was reported as normal. It was thought that the blurriness in the vision could be caused by drug-induced eosinophil infiltration. This case is presented as a rare case of DRESS syndrome with blurred vision. Keywords: drug-induced hypersensitivity syndrome, anticonvulsant treatment, blurred vision