Open AccessFREQUENCY OF INCREASED PLASMA C-PEPTIDE LEVELS IN COLORECTAL CANCER PATIENTS
Author(s) -
Muhammad Mubasher Saleem,
Shazia Nisar,
Muhammad Mubasher Saleem,
Husnain Saleem,
Shoaib Mukhtar,
Muhammad Anjum
Publication year - 2021
Publication title -
pakistan armed forces medical journal
Language(s) - English
Resource type - Journals
eISSN - 2411-8842
pISSN - 0030-9648
DOI - 10.51253/pafmj.v71i6.3685
Subject(s) - colorectal cancer , medicine , peptide , gastroenterology , cancer , endocrinology , chemistry , biochemistry
Objective: To assess the increased frequency of serum C-peptide levels in patients of colorectal carcinoma.
Study Design: Cross sectional study.
Place and Duration of Study: Combined Military Hospital, Rawalpindi Pakistan, from Jul 2018 to Jan 2019.
Methodology: A total of 100 cases of colorectal carcinoma were enrolled. Blood samples were obtained to assess C-peptide level. The C-peptide serum concentrations were deliberate through the Cobas 6000 by using the electro-chemi-luminescence immunoassay (ECLIA) method. If level of C-peptide was >2 pmol/mL, then it was noted.
Results: The mean age of all patients was 58.3 ± 5.4 years. There was a total of 136 (68%) females and 64 (32%) were males. The mean BMI of patients was 28.96 ± 12.31 kg/m2. The family history of colorectal carcinoma was positive in 6 (6%) cases. The mean C-peptide level was 4.55 ± 2.37 pmol/L. There were 33 (33%) patients with raised C-peptide level while 67 (67%) had normal c-peptide level.
Conclusion: It is concluded that increased C-peptide level is high in patients with colorectal cancer.