Open AccessEXPRESSION OF ERG IMMUNOHISTOCHEMICAL STAIN IN PROSTATIC ADENOCARCINOMA
Author(s) -
Sana Tabish,
Erum Yousuf Khan,
Sajid Mushtaq,
Usman Hassan,
Mudassar Hussain
Publication year - 2021
Publication title -
pakistan armed forces medical journal
Language(s) - English
Resource type - Journals
eISSN - 2411-8842
pISSN - 0030-9648
DOI - 10.51253/pafmj.v71i3.5518
Subject(s) - erg , medicine , prostatic adenocarcinoma , immunohistochemistry , stain , adenocarcinoma , staining , incidence (geometry) , pathology , cancer , ophthalmology , retinal , physics , optics
Objective: The objective of my study is to investigate the incidence ERG fusion positive adenocarcinoma and its correlation with gleason grade and gleason group.
Methods: it is a descriptive cross sectional study. 100 cases of prostatic adenocarcinoma were retrieved and ERG immunohistochemical stain was applied on all these cases. ERG expression, extent of staining, percentage of tumor cells positive for ERG, pattern of staining were recorded. We found out relationship of ERG expression and gleason grade/ gleason group.
Results: ERG expression was seen in 62/100 (62%) cases. mean patient age of ERG positive prostatic adenocarcinoma patients was 69.68years. In GG1 (14.5%) 9 cases exhibited ERG positivity. In GG2-3, 41.93% cases and in GG4-5, 43.54% cases showed ERG expression.
Conclusion: To conclude, age of presentation of ERG positive adenocarcinoma was high. ERG expression was seen in 62% of our cases which was much higher than reported in other Asian countries. In our study we found a significant correlation between ERG expression and high gleason grade group.