Open AccessIn vitro antioxidant and antifungal activity of methanol root extract of Flacourtia indica (Burm.f.) Merr. against selected fungal species
Author(s) -
N Eramma,
Devaraja Gayathri
Publication year - 2021
Publication title -
biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.106
H-Index - 9
ISSN - 0970-2067
DOI - 10.51248/.v41i3.1218
Subject(s) - aspergillus niger , traditional medicine , antioxidant , dpph , trichophyton rubrum , trichophyton , antifungal , chemistry , aspergillus flavus , biology , botany , microbiology and biotechnology , food science , biochemistry , medicine
and Aim: Flacourtia indica (Burm.f.) Merr. is a member of the family Flacourtiaceae. This herb was used to treat a range of ailments and served as the foundation for ethnomedicine. Despite its enormous medical importance, the plant has received very little research with only a few antibacterial and pharmacological studies. The plant's roots, in particular, are understudied. In this study, the antioxidant and antifungal activities of methanol (MeOH) root extract of F. indica was tested in vitro. Materials and Methods: Antifungal activity was assessed against human fungal pathogens, Aspergillus niger (MTCC 404) and Trichophyton mentagrophytes (MTCC 7687). The natural antioxidants in roots were studied using five different antioxidant methods, including 2, 2-diphenyl-1-picrylhydrazyl (DPPH), nitric oxide scavenging (NOS), reducing power assay (RPA), measuring total phenolic content (TPC) by Folin-Ciocalteu Reagent (FCR). Results: When compared to Aspergillus niger, the root extract has strong antifungal activity against Trichophyton mentagrophytes (MTCC 7687), generating a broader zone of inhibition (MTCC 404). Clotrimazole is a common antifungal medicine that can be used as a positive control in this investigation. The antioxidant activity of MeOH root extract increased in a dose-dependent manner, and it had outstanding NOS and antioxidant properties. Conclusion: The results conclude that, F. indica appears to be a promising herbal option for the treatment of a variety of fungal and bacterial infections, with high antioxidant capacity.