Open AccessDec2 inhibits macrophage pyroptosis to promote periodontal homeostasis
Author(s) -
Dalin He,
Xiaoyan Li,
Fengzhu Zhang,
Chen Wang,
Yi Liu,
Ujjal K. Bhawal,
Ju Sun
Publication year - 2022
Publication title -
journal of periodontal and implant science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 26
eISSN - 2093-2286
pISSN - 2093-2278
DOI - 10.5051/jpis.2101380069
Subject(s) - pyroptosis , inflammation , porphyromonas gingivalis , lipopolysaccharide , periodontitis , tumor necrosis factor alpha , macrophage , immunology , immune system , proinflammatory cytokine , cytokine , chemistry , inflammasome , medicine , in vitro , biochemistry
Macrophages play crucial roles as early responders to bacterial pathogens and promote/ or impede chronic inflammation in various tissues. Periodontal macrophage-induced pyroptosis results in physiological and pathological inflammatory responses. The transcription factor Dec2 is involved in regulating immune function and inflammatory processes. To characterize the potential unknown role of Dec2 in the innate immune system, we sought to elucidate the mechanism that may alleviate macrophage pyroptosis in periodontal inflammation.