Open AccessAzidothymidine Downregulates Insulin-Like Growth Factor-1 Induced Lipogenesis by Suppressing Mitochondrial Biogenesis and Mitophagy in Immortalized Human Sebocytes
Author(s) -
Jin Gwi Yoo,
Xue Mei Li,
Jae Kwan Lee,
Sanghyun Park,
Dongkyun Hong,
Kwang Hwa Jung,
Young Lee,
YoungJoon Seo,
Chang Deok Kim,
Jung-Hye Shin,
Chong Won Choi
Publication year - 2021
Publication title -
annals of dermatology/annals of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.385
H-Index - 37
eISSN - 2005-3894
pISSN - 1013-9087
DOI - 10.5021/ad.2021.33.5.425
Subject(s) - lipogenesis , mitophagy , mitochondrial biogenesis , mitochondrion , oil red o , downregulation and upregulation , endocrinology , biogenesis , lipid droplet , medicine , lipid metabolism , biology , microbiology and biotechnology , biochemistry , adipose tissue , apoptosis , adipogenesis , gene , autophagy
Increased sebum secretion is considered the main causative factor in the pathogenesis of acne. There is an unmet pharmacological need for a novel drug that can control sebum production with a favorable adverse effect profile.