Open AccessToll-Like Receptor 7 (TLR7) Mediated Transcriptomic Changes on Human Mast Cells
Author(s) -
KyungAh Cho,
Da Won Choi,
Minhwa Park,
Yu Hee Kim,
So Youn Woo
Publication year - 2021
Publication title -
annals of dermatology/annals of dermatology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.385
H-Index - 37
eISSN - 2005-3894
pISSN - 1013-9087
DOI - 10.5021/ad.2021.33.5.402
Subject(s) - tlr7 , mast cell , immunoglobulin e , toll like receptor , immunology , microbiology and biotechnology , innate immune system , immune system , tryptase , inflammation , interleukin 33 , receptor , medicine , pattern recognition receptor , biology , antibody , cytokine , interleukin
Mast cells are skin immune sentinels located in the upper dermis, where wheal formation and sensory nerve stimulation take place. Skin inflammation is occasionally accompanied by mast cell-driven responses with wheals, angioedema, or both. Immunoglobulin E (IgE) antibodies are regarded as typical stimuli to drive mast cell activation. However, various causative factors, including microbial infections, can drive IgE-independent mast cell response. When infected, the innate immunity orchestrates an immune response by activating receptor signaling via Toll-like receptors (TLRs).