Open AccessPotential Role of Cytosolic RNA Sensor MDA5 as an Inhibitor for Keratinocyte Differentiation in the Pathogenesis of Psoriasis
Author(s) -
Dongkyun Hong,
Mira Choi,
Yul-Lye Hwang,
Jae Kwan Lee,
Young Lee,
YoungJoon Seo,
Soo-Il Kim,
Chang Deok Kim,
JeungHoon Lee
Publication year - 2021
Publication title -
annals of dermatology/annals of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.385
H-Index - 37
eISSN - 2005-3894
pISSN - 1013-9087
DOI - 10.5021/ad.2021.33.4.339
Subject(s) - mda5 , psoriasis , keratinocyte , medicine , pathogenesis , cancer research , dermatology , immunology , microbiology and biotechnology , rna , biology , gene , cell culture , genetics , rna interference
Psoriasis is a chronic inflammatory skin disease. The etiology of psoriasis is not fully understood, but the genetic background is considered to be the most important factor. To date, many psoriasis-related genes have been discovered, but the role of many important genes has not been well understood.