Open AccessImmunohistochemical Analysis of Prurigo Nodularis in 209 Patients: Clinicopathological Analysis between Atopic and Non-Atopic Patients and between Treatment Response Groups
Author(s) -
Hyun Jeong Byun,
Donghwi Jang,
DongYoun Lee,
JunMo Yang
Publication year - 2021
Publication title -
annals of dermatology/annals of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.385
H-Index - 37
eISSN - 2005-3894
pISSN - 1013-9087
DOI - 10.5021/ad.2021.33.4.333
Subject(s) - medicine , prurigo , prurigo nodularis , pathogenesis , atopic dermatitis , hyperplasia , immunohistochemistry , mast cell , enolase , itching , giemsa stain , staining , pathology , cytokeratin , dermatology , immunology
Prurigo nodularis (PN) is a highly pruritic disease that significantly impairs patient quality of life. Although the mechanism that causes pruritus is not clear, one hypothesis argues that neural hyperplasia, mast cell, and Merkel cell neurite complexes may be associated with PN pathogenesis.