Open AccessCurrent Understanding of Transfusion-associated Necrotizing Enterocolitis: Review of Clinical and Experimental Studies and a Call for More Definitive Evidence
Author(s) -
Praveen Kumar,
Parvesh Mohan Garg,
Isabelle G. De Plaen,
Robert D. Christensen,
Minesh Khashu,
Christof Dame,
Pascal Lavoie,
Venkatesh Sampath,
Atul Malhotra,
Michael D Caplan,
Pankaj B. Agrawal,
Giuseppe Buonocore,
Akhil Maheshwari
Publication year - 2022
Publication title -
newborn
Language(s) - English
Resource type - Journals
ISSN - 2769-514X
DOI - 10.5005/jp-journals-11002-0005
Subject(s) - necrotizing enterocolitis , medicine , anemia , intensive care medicine , randomized controlled trial , red blood cell , erythropoiesis , immunology , pediatrics
The association between red blood cell (RBC) transfusions and necrotizing enterocolitis (NEC), so-called transfusion-associated NEC (ta-NEC), was first described in 1987. However, further work is needed to confirm a causal relationship, elucidate underlying mechanisms, and develop possible strategies for prevention. We performed an extensive literature search in the databases PubMed, EMBASE, and Scopus.