Open AccessDirect Measurement of Creatinine Clearance over a Short Interval in Intensive Care Settings
Author(s) -
Lawrence Siu-Chun Law,
Elaine Ah-Gi Lo,
Siang Fei Yeoh
Publication year - 2021
Publication title -
indian journal of critical care medicine/indian journal of critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 30
eISSN - 1998-359X
pISSN - 0972-5229
DOI - 10.5005/jp-journals-10071-23825
Subject(s) - medicine , creatinine , renal function , acute kidney injury , intensive care , confidence interval , urology , urine , renal replacement therapy , diuresis , intensive care unit , intensive care medicine
The definition of acute kidney injury (AKI), based on serum creatinine and urine output, bears significant limitations in intensive care units (ICUs). Serum creatinine has significant lag-time as it needs to be accumulated and stabilized at a new level whereas urine output is affected by diuresis, antidiuresis, and antinatriuresis. Direct measurement of creatinine clearance (CrCl direct = urine creatinine × urine flow rate/serum creatinine) over a short interval (3-6 hours) was explored to identify patients with AKI.