Open AccessCrosstalk between T Helper Cell Subsets and Their Roles in Immunopathogenesis and Outcome of Polytrauma Patients
Author(s) -
Surbhi Khurana,
Nidhi Bhardwaj,
Subodh Kumar,
Sushma Sagar,
Rahul Pal,
Kapil Dev Soni,
Richa Aggarwal,
Rajesh Malhotra,
Purva Mathur
Publication year - 2020
Publication title -
indian journal of critical care medicine/indian journal of critical care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.317
H-Index - 30
eISSN - 1998-359X
pISSN - 0972-5229
DOI - 10.5005/jp-journals-10071-23577
Subject(s) - polytrauma , medicine , immune system , t helper cell , immunology , irf4 , t cell , transcription factor , biology , surgery , gene , biochemistry
One of the leading causes of morbidity and early-age mortality across the globe is trauma. It disrupts immune system homeostasis and intensely affects the innate and adaptive immune responses, predisposing patients to posttrauma complications and poor outcomes. Most of the studies on posttrauma cellular immune response have been centered on the T helper-1-T helper-2 imbalances after trauma. This study was conducted to understand the role of circulating novel T helper cells in the acute posttraumatic period and clinical outcome of trauma patients.