Open AccessTacrolimus-associated Pruritus: A Case Report and Review
Author(s) -
Shambo Samrat Samajdar
Publication year - 2021
Publication title -
bengal physician journal
Language(s) - English
Resource type - Journals
ISSN - 2582-1202
DOI - 10.5005/jp-journals-10070-7018
Subject(s) - tacrolimus , calcineurin , everolimus , medicine , sirolimus , protein synthesis inhibitor , dermatology , adverse effect , intensive care medicine , pharmacology , transplantation , antibiotics , antibacterial agent , microbiology and biotechnology , biology
The use of immunosuppressants following solid organ transplantation has become a general procedure nowadays. Various immunosuppressants have been used—among them tacrolimus, is a calcineurin inhibitor (CNI) and macrolide antibiotic has been chosen widely. But significant complaints associated with tacrolimus have been reported, for example, severe pruritus. As a result, physicians are required to substitute this one without compromising the intended therapeutic effect, minimizing adverse drug reactions. Everolimus becomes the best alternative, which is also a mammalian target of rapamycin (mTOR) inhibitor with a comparatively wide therapeutic index as compared to tacrolimus. This present reporting is about the tacrolimus-associated pruritus which was severe and how the patient compliance has been ensured keeping in mind the other comorbidities. How to cite this article: Sen S, Tripathi SK, Samajdar SS. Tacrolimus-associated Pruritus: A Case Report and Review. Bengal Physician Journal 2020;7(1):12–13.