Current Concepts about Areca Nut Chewing

The habit of chewing areca is a habit of great antiquity. The word ‘areca’ is derived from the Malay word adakka (areca nut) or from adakeya, the Indian equivalent. Arecoline, the principal alkaloid in areca nut, acts as an agonist primarily at muscarinic acetylcholine receptors and stimulates the central and autonomic nervous system. This leads to subjective effects of increased well-being, alertness and stamina. It is known to improve concentration and relaxation, with other reported effects including lifting of mood, cariostatic property and also exerts a direct antimicrobial effect against bacteria. Arecaidine may have anxiolytic properties through inhibition of gamma-amino butyric acid (GABA) reuptake. Despite these general effects, the adverse effects have outweighed them. Betal quid chewing is one of the major risk factors of hepatocarcinoma, oropharyngeal and esophagus cancers. Arecoline, the main areca alkaloid of the betel nut, is reported to have cytotoxic, genotoxic and mutagenic effects in various cells. It shows strong correlation to the incidence of oral submucosal fibrosis, leukoplakia and oral cancer, and has also been found to impose toxic manifestations in immune, hepatic and other defense systems of the recipient. How to cite this article Chandak RM, Chandak MG, Rawlani SM. Current Concepts about Areca Nut Chewing. J Contemp Dent 2013;3(2):78-81.