Open AccessNucleoside Analog-treated Chronic Hepatitis B Patients showed Reduced Expression of PECAM-1 Gene in Peripheral Blood Mononuclear Cells in Bangladesh
Author(s) -
Nusrat Sultana,
Shahina Tabassum,
Saif Ullah Munshi,
M. Nur Hossain,
Akhter Imam
Publication year - 2013
Publication title -
euroasian journal of hepato-gastroenterology
Language(s) - English
Resource type - Journals
eISSN - 2231-5128
pISSN - 2231-5047
DOI - 10.5005/jp-journals-10018-1108
Subject(s) - peripheral blood mononuclear cell , medicine , nucleoside , immunology , hbeag , hepatitis b virus , nucleoside analogue , viral load , immune system , hepatitis b , biomarker , gene expression , virus , gene , biology , hbsag , in vitro , biochemistry
Assessment of therapeutic response is important for monitoring the prognosis and to take decision for cessation of nucleoside analogues therapy in chronic hepatitis B patients. In addition to serum alanine aminotransferase (ALT), hepatitis B virus (HBV) deoxyribonucleic acid (DNA) load and HBeAg status, identification of molecular markers associated with host immune response would be essential to assess therapeutic response. In this regard the current study was performed with the aim to detect expression of platelet endothelial cell adhesion molecule (PECAM)-I gene in peripheral blood monocytes (PBMCs) of treated chronic hepatitis B patients and also to correlate expression of this gene with serum HBV DNA load and serum ALT levels.