Open AccessEvaluation of the Role of -137G/C Single Nucleotide Polymorphism (rs187238) and Gene Expression Levels of the IL-18 in Patients with Coronary Artery Disease
Author(s) -
Fatemeh Hoseini,
Sanaz Mahmazi,
Khalil Mahmoodi,
Gholam Ali Jafari,
Mohammad Soleiman Soltanpour
Publication year - 2018
Publication title -
oman medical journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 31
eISSN - 2070-5204
pISSN - 1999-768X
DOI - 10.5001/omj.2018.23
Subject(s) - coronary artery disease , medicine , genotype , odds ratio , allele , single nucleotide polymorphism , gastroenterology , proinflammatory cytokine , gene , immunology , genetics , biology , inflammation
Interleukin-18 (IL-18) is a proinflammatory and proatherogenic cytokine, and its genetic variations may contribute to the development of coronary artery disease (CAD). We sought to investigate the role of -137G/C polymorphism and gene expression levels of IL-18 in patients with CAD.