Synthesis, Characterization and Biological Activity of Some Mixed Ligand Transitionmetal Complexes

The Schiff bases derived from Salicylaldehyde with substituted amines and alpha benzoin oxime as a primary ligand are prepared by mixed with Cobalt (II), Nickel(II) and Copper (II). Structure have been proposed from elemental examination, like IR, NMR, thermal examination and magnetic susceptibility, Spectroscopic studies suggests that coordination occurs through azomethine nitrogen, hydroxyl group and oxime of the ligand to the metal ions. Elemental analysis of Schiff bases, alpha benzoin oxime and metal complexes are confirmed to stoichiometry of the type ML1L2 where Metals are Cobalt (II) andNickel (II) L1 are Schiff bases and L2 are alpha benzoin oxime. The mixed ligand Co(II) complexes were synthesize by using α-benzoin oxime as a primary ligand and Schiff base prepared from salicylaldehyde and chloroanilines with hydroxyanilines as a secondary ligand. The metal complexes have been characterized different elemental analyses and various chemical techniques such as molar conductance, magnetic susceptibility, infrared, NMR, spectral studies and thermal analysis. The elemental analysis data is consistent with their general formulation as mixed ligand complexes MLL’.xH2O. The bondings and structures of the complexes are discussed in detail on the basis of the results of various chemical studies. All of these metal complexes and ligands have been screened for their biological activities against selected pathogenic microbial strains. The Ditch Plate Method has been used to study the antibacterial activity against E. coli, S. typhi, S. aureusandS. pyogenes.