Open AccessSynthesis of 2-Mercapto Substituted Quinazolin-4(3H)-One Derivatives using β-Cyclodextrin in Aqueous Medium
Author(s) -
Balaswamy Puligilla,
Bala Narsihma Dhoddi,
Yadagiri Rao Yasala,
Muthaiah Chintha
Publication year - 2022
Publication title -
international journal of advanced research in science, communication and technology
Language(s) - English
Resource type - Journals
ISSN - 2581-9429
DOI - 10.48175/ijarsct-2530
Subject(s) - quinazolinone , aqueous medium , chemistry , cyclodextrin , catalysis , gram , aqueous solution , thio , organic chemistry , combinatorial chemistry , bacteria , biology , genetics
An expedient, mild and highly efficient green synthesis of 3-mercapto Quinazolinone derivatives were synthesized using β-cyclodextrin as a phase transfer catalyst in the aqueous medium. 3-mercapto Quinazolinones employed with halo-acyl/halo-alkyl groups in β-cyclodextrin/water medium obtained thio-ethers. The resulting compounds anti-bacterial studies were carried out against Gram-ve and Gram+ve bacteria.