Synthesis of 2-Mercapto Substituted Quinazolin-4(3H)-One Derivatives using β-Cyclodextrin in Aqueous Medium

An expedient, mild and highly efficient green synthesis of 3-mercapto Quinazolinone derivatives were synthesized using β-cyclodextrin as a phase transfer catalyst in the aqueous medium. 3-mercapto Quinazolinones employed with halo-acyl/halo-alkyl groups in β-cyclodextrin/water medium obtained thio-ethers. The resulting compounds anti-bacterial studies were carried out against Gram-ve and Gram+ve bacteria.