Open AccessSynthesis, Characterization and Biological Evaluation of 4-(4-Bromo-1-Hydroxy Naphthalen-2-Yl)-6-(4-Methoxy Phenyl)-5,6-Dihydropyrimidine-2(1h)-One
Author(s) -
V. M. Sherekar,
K. P. Kakade,
Nilesh S. Padole
Publication year - 2021
Publication title -
international journal of advanced research in science, communication and technology
Language(s) - English
Resource type - Journals
ISSN - 2581-9429
DOI - 10.48175/ijarsct-2446
Subject(s) - benzaldehyde , chemistry , antimicrobial , acetic acid , urea , medicinal chemistry , nuclear chemistry , organic chemistry , catalysis
1-(4- Bromo -1-hydroxynaphthalen-2-yl)-ethan-1-one was prepared by refluxing 4- bromonaphthalen-1-ol with glacial acetic acid in presence of fused ZnCl2. By condensing 1-(4- bromo -1-hydroxynaphthalen-2- yl)-ethan-1-ones with 4- methoxy benzaldehyde, to prepared by 1-(4- bromo -1- hydroxynaphthalen-2-yl)-3-(4-methoxy phenyl)-prop-2-en-1-one were synthesized.1-(4- bromo -1- hydroxynaphthalen-2-yl)-3-(4-methoxy phenyl)-prop-2-en-1-one, urea and concentrated HCl in DMF were added and refluxed. Cool and pour in crushed ice. Treat it with cold NH4OH solution to obtain titled compounds. The compounds thus synthesized have been characterized by physical and spectral data. All of these titled synthesized compounds have been screened for antimicrobial study and are found to possess excellent antimicrobial activities.