Open AccessA Convenient Green Protocol for the Synthesis of 4-Arylmethylidene-3-substituted-isoxazol-5(4H)-ones catalysed by Dimethylaminopyridine (DMAP)
Author(s) -
Nitishkumar S. Kaminwar
Publication year - 2021
Publication title -
international journal of advanced research in science, communication and technology
Language(s) - English
Resource type - Journals
ISSN - 2581-9429
DOI - 10.48175/ijarsct-2355
Subject(s) - hydroxylamine hydrochloride , chemistry , reagent , catalysis , hydroxylamine , hydrochloride , organic chemistry , medicinal chemistry
Isoxazolemotif containing heterocyclic compounds are important for their wide range of biological activities. Therefore, in the present article, I report a convenient and green protocol for the synthesis of 4-arylmethylidene-3-substituted-isoxazol-5(4H)-ones by the one pot three component reaction of aldehydes, β-keto ester and hydroxylamine hydrochloride catalyzed by Dimethylaminopyridine (DMAP). 1 (a-i) 2(a-b) 3 (4a-f), (5a-i)Scheme 1: Reagent and conditions:(i) Dimethylaminopyridine (DMAP), H2O (5 mL), 70- 800C, 6 to 25 min.