A Convenient Green Protocol for the Synthesis of 4-Arylmethylidene-3-substituted-isoxazol-5(4H)-ones catalysed by Dimethylaminopyridine (DMAP) | Zendy

Nitishkumar S. Kaminwar | Zendy

Open Access

A Convenient Green Protocol for the Synthesis of 4-Arylmethylidene-3-substituted-isoxazol-5(4H)-ones catalysed by Dimethylaminopyridine (DMAP)

Author(s) -

Nitishkumar S. Kaminwar

Publication year - 2021

Publication title -

international journal of advanced research in science communication and technology

Language(s) - English

Resource type - Journals

ISSN - 2581-9429

DOI - 10.48175/ijarsct-2355

Subject(s) - hydroxylamine hydrochloride , chemistry , reagent , catalysis , hydroxylamine , hydrochloride , organic chemistry , medicinal chemistry

Isoxazolemotif containing heterocyclic compounds are important for their wide range of biological activities. Therefore, in the present article, I report a convenient and green protocol for the synthesis of 4-arylmethylidene-3-substituted-isoxazol-5(4H)-ones by the one pot three component reaction of aldehydes, β-keto ester and hydroxylamine hydrochloride catalyzed by Dimethylaminopyridine (DMAP). 1 (a-i) 2(a-b) 3 (4a-f), (5a-i)Scheme 1: Reagent and conditions:(i) Dimethylaminopyridine (DMAP), H2O (5 mL), 70- 800C, 6 to 25 min.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research