Open AccessSynthesis of Some New 1,3,4- Oxadiazole Derivatives and Thiazolidine Derived from Cysteine and Evaluation their Anticancer (MCF7) Activity
Author(s) -
Ahmed A. Majed,
Dawood S Abid
Publication year - 2022
Publication title -
biomedicine and chemical sciences
Language(s) - English
Resource type - Journals
eISSN - 2957-5826
pISSN - 2790-296X
DOI - 10.48112/bcs.v1i2.109
Subject(s) - thiazolidine , chemistry , oxadiazole , hydrazide , benzaldehyde , acetic acid , organic chemistry , ethanol , yield (engineering) , aldehyde , acetic anhydride , combinatorial chemistry , medicinal chemistry , catalysis , materials science , metallurgy
The study focused on the preparation of oxadiazole derivatives containing thiazolidine. Thiazolidine firstly was prepared from the reaction of benzaldehyde with L-cysteine with a good yield and then it was reacted with acetic anhydride to prepare acetyl thiazolidine, then with ethanol in the presence of H2SO4, then steps were taken to prepare a thiazolidine hydrazide (A3), which was reacted with aromatic carboxylic acid in presence POCl3 or carbon disulphide and base KOH to obtain oxadiazole derivatives A4-8. These compounds characterized using FT-IR, NMR and Mass (EI) were diagnosed and the synthesized compound were validated. The activity of oxadiazole derivatives were studied against breast cancer cells, the two compound A8, A4 showed good activity against the cells as for the compounds A5, A6, A7 it was showed little activity against these cells and the value IC50 was calculated.