Assembly of tetraspanins, galectin-3, and distinct N-glycans defines the solubilization signature of seminal prostasomes from normozoospermic and oligozoospermic men | Zendy

Tamara Janković | Zendy; Jelena Danilović Luković | Zendy; Irena Miler | Zendy; Ninoslav Mitić | Zendy; Ljiljana Hajduković | Zendy; Miroslava Janković | Zendy

Open Access

Assembly of tetraspanins, galectin-3, and distinct N-glycans defines the solubilization signature of seminal prostasomes from normozoospermic and oligozoospermic men

Author(s) -

Tamara Janković,

Jelena Danilović Luković,

Irena Miler,

Ninoslav Mitić,

Ljiljana Hajduković,

Miroslava Janković

Publication year - 2021

Publication title -

upsala journal of medical sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.808

H-Index - 41

eISSN - 2000-1967

pISSN - 0300-9734

DOI - 10.48101/ujms.v126.7673

Subject(s) - wheat germ agglutinin , lectin , galectin , glycoprotein , concanavalin a , glycan , agglutinin , solubilization , vesicle , biology , microbiology and biotechnology , biochemistry , chemistry , membrane , in vitro

Prostasomes, extracellular vesicles (EVs) abundantly present in seminal plasma, express distinct tetraspanins (TS) and galectin-3 (gal-3), which are supposed to shape their surface by an assembly of different molecular complexes. In this study, detergent-sensitivity patterns of membrane-associated prostasomal proteins were determined aiming at the solubilization signature as an intrinsic multimolecular marker and a new parameter suitable as a reference for the comparison of EVs populations in health and disease.

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