Open AccessMetabolic plasticity of cancer cells
Author(s) -
Martina Raudenská,
Michal Masařík,
Barbora Peltanová,
Kateřina Hönigová,
Jiří Navrátil,
Michal Masařík
Publication year - 2022
Publication title -
klinická onkologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.204
H-Index - 13
eISSN - 1802-5307
pISSN - 0862-495X
DOI - 10.48095/ccko2022195
Subject(s) - cancer cell , carcinogenesis , metabolic pathway , biology , tumor microenvironment , extracellular , cancer , reprogramming , metabolism , microbiology and biotechnology , intracellular , cell metabolism , cancer research , flexibility (engineering) , cell , tumor cells , biochemistry , genetics , statistics , mathematics
A general characteristic of cancer metabolism is the skill to gain the essential nutrients from a relatively poor environment and use them effectively to maintain viability and create new bio-mass. The changes in intracellular and extracellular metabolites that accompany metabolic reprogramming associated with tumor growth subsequently affect gene expression, cell differentiation, and tumor microenvironment. During carcinogenesis, cancer cells face huge selection pressures that force them to constantly optimize dominant metabolic pathways and undergo major metabolic reorganizations. In general, greater flexibility of metabolic pathways increases the ability of tumor cells to satisfy their metabolic needs in a changing environment.