Open AccessChanges of serum protein N-glycosylation in cancer
Author(s) -
Iva Benešová,
Adam Urminsky,
Jana Halámková,
Lenka Hernychová
Publication year - 2022
Publication title -
klinická onkologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.204
H-Index - 13
eISSN - 1802-5307
pISSN - 0862-495X
DOI - 10.48095/ccko2022174
Subject(s) - glycosylation , glycan , glycomics , biology , n linked glycosylation , glycoprotein , biochemistry , computational biology
Glycosylation is a posttranslational modification responsible for many bio-logical processes including protein-protein interactions, cell signaling or cell cycle regulation. Changes in glycosylation of serum proteins reflects the status of tissues and cells in the organism and therefore can be used as markers for dia-gnosis of cancer, its progression and determination of its subtypes. N-glycan profiling is often used for characterization of N-glycosylation changes. It is based on the measurements of N-glycans released from the serum proteins. Beside the N-glycan profiling, glycoproteomic approach is emerging as it preserves the information about glycan composition, original protein, and its glycosylation sites.