Open AccessThe place and importance of hyaluronic acid in radiotherapy side effects
Author(s) -
Yasemin Benderli Cihan
Publication year - 2021
Publication title -
klinická onkologie
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.204
H-Index - 13
eISSN - 1802-5307
pISSN - 0862-495X
DOI - 10.48095/ccko2021346
Subject(s) - hyaluronic acid , dermis , extracellular matrix , angiogenesis , radiation therapy , wound healing , catabolism , medicine , umbilical cord , side effect (computer science) , cell , chemistry , cancer research , surgery , pathology , biochemistry , immunology , anatomy , metabolism , computer science , programming language
Hyaluronic acid (HA) is one of the largest and most important components of the extracellular matrix. It is found in high amounts in the vitreous humor, umbilical cord, dermis, synovial fluid and heart valves. Up to 80-90% of the circulating HA undergoes catabolism in the liver and 10% is eliminated by the kidney. It is widely used in many branches of medicine. Studies have demonstrated that it provides angiogenic and anti-adhesive effect, collagen storage, cell-cell and cell-matrix interactions, balancing osmotic pressure, removing waste, balancing the distribution of high molecular weight proteins and increasing angiogenesis; it has inflammatory effect, provides wound healing and immunostimulators. Along with its basic features, it can undertake different tasks according to the tissue it is in and the cell type it is secreted from. Neither contraindications nor interactions with drugs have been reported to date. When the literature is reviewed, HA appears to be an effective and safe option in the treatment of acute and chronic side effects that will occur or occur due to radiotherapy. However, there is a need for researches on how HA can be used and how long it can be used.