Pharmacodynamic drug interactions

Pharmacodynamic interactions are manifested by a change in pharmacological effect at the site of action. There may be a synergistic action, a potentiation or antagonism. Pharmacodynamic interactions are predictable and preventable since the mechanisms of drug action are defined in advance, the interaction drug-target is systematically described and various effectors and signal transduction systems are highlighted. Any time the plurality of molecular targets of the same drug should be considered when prescribing. The wide diffusion of pharmacological information and the updating of knowledge are then two tools to manage this kind of interaction.