Open AccessThe Effect of Particle Size on the Physical Characteristics and Drug-release Behavior of Mini-tablets
Author(s) -
Awis Sukarni Mohmad Sabere,
Mohd Muzamir Mahat
Publication year - 2021
Publication title -
trends in sciences
Language(s) - English
Resource type - Journals
ISSN - 2774-0226
DOI - 10.48048/tis.2021.43
Subject(s) - particle size , sieve (category theory) , materials science , dissolution , peg ratio , sieve analysis , absorption of water , particle (ecology) , chromatography , composite material , chemical engineering , chemistry , nanotechnology , mathematics , organic chemistry , finance , combinatorics , engineering , economics , oceanography , geology
This study aimed to investigate the influence of particle size of the excipients on the behavior of mini-tablets in terms of physical characteristics and drug release profiles. Material and methods: All of the mini-tablets based on HPMC, PEG 6K and PEO 8M PVP produced high quality mini-tablets from both sieve fractions while 90F was very fragile. Results: Crushing strength values were the most pronounced difference between the mini-tablets from all formulations. The PEO 8M-based mini-tablets showed the highest values and deformation behavior instead of fracture. Water absorption and drug release profiles also showed intriguing and different results between the various formulations. Conclusion: The results suggested that even though different particle size has limited effect on the physical characteristic of the product, it may have a significant effect on its drug dissolution profile.HIGHLIGHTSThe particle size of powders or granules can influence the physical properties and release profiles of tablets, particularly mini-tabletsPEG 6K and PEO 8M mini-tablets from the larger sieve fraction variation absorbed less moisture and released drugs faster than their counterparts, whereas HPMC and PVP 90F mini-tablets from both sieve fractions exhibited a similar pattern in terms of moisture uptake and drug release profilesPEO 8M mini-tablets of both sieve fractions displayed almost linear release profiles with the highest crushing strength than the rest of the formulationsGRAPHICAL ABSTRACT