Open AccessAnti-Fungal Efficacy and Secondary Metabolite Analysis of the Methanolic Extract from Colpomenia peregrina towards Opportunistic Fungal Pathogens
Author(s) -
Vishnu Kiran Manam
Publication year - 2021
Publication title -
international journal for innovative engineering and management research
Language(s) - English
Resource type - Journals
ISSN - 2456-5083
DOI - 10.48047/ijiemr/v10/i09/13
Subject(s) - microsporum gypseum , aspergillus fumigatus , cryptococcus neoformans , aspergillus flavus , microbiology and biotechnology , candida albicans , biology , cryptococcus , aspergillus , antifungal , trichophyton
The present study illustrates the antifungal efficacy of methanolic extract from marine brownseaweed Colopomenia peregrina gathered from Leepuram coast, South India, towardsopportunistic fungal pathogens comprising of dermatophytes, non-dermatophytes, and yeasts.The opportunistic fungal pathogens used in the study are Aspergillus flavus (ATCC 27692),Aspergillus fumigatus (ATCC 19673), Microsporum gypseum (ATCC 24102), Cryptococcusneoformans (ATCC 14116), and Candida albicans (ATCC14053) which are commonlyresponsible for nosocomial infections. The NMR analysis revealed the presence of variouschemical shifts showing the presence of protons containing Hydroxyl, Methoxy, Methylgroups, and –COO-CH2 groups.The presence of phytochemicals from the extract of seaweedconfirmed the nutritional profile. The results revealed greater efficacy of methanolic extracttowards Aspergillus fumigatus, Microsporum gypseum, Cryptococcus neoformans, and loweractivity with Aspergillus flavus and Candida albicans compared with the standard anti-fungalfluconazole.