Open AccessTOMOGRAFÍA DE COHERENCIA ÓPTICA COMO MARCADOR PARA LAS ENFERMEDADES NEURODEGENERATIVAS DE ALZHEIMER Y PARKINSON.
Author(s) -
Victoria Coba,
Cristina Paredes,
Jorge Rivera
Publication year - 2021
Publication title -
vozandes
Language(s) - English
Resource type - Journals
ISSN - 1390-1656
DOI - 10.48018/rmv.v32.i1.4
Subject(s) - medicine , nerve fiber layer , biomarker , retinal , parkinson's disease , substantia nigra , disease , optical coherence tomography , retina , ophthalmology , pathology , neuroscience , psychology , biology , biochemistry
Background: Optical coherence tomography (OCT) is an ancillary test used in retinal pathology. The objective of the present dissertation is to review literature regarding (OCT) and its importance as a biomarker in neurodegenerative Alzheimer’s and Parkinson’s disease, through an analysis of medical journal articles published between 2015 and 2019. Methods: A retrospective systematic review without meta-analysis of literature was carried out using observational research design, allowing to summarize the results of multiple primary investigations. Ten studies published between 2015 and 2019 regarding the application of OCT and ANGIO OCT in adult patients older than 60 years of age with preclinical Alzheimer’s disease (AD) or Parkinson’s disease (PD) with retinal microvascular abnormalities, were selected. Results: Areas of increased thickness of ganglion cell-inner plexiform layer (GCIPL) and nerve fiber layer (NFL) adyacent to the macula suggest that dynamic changes can occur as a result of AD progression. Thinning of the retina is present during early stages of PD. This correlates with disease severity and may be related to degeneration of dopaminergic neurons in the substantia nigra. Conclusion: Optical Coherence Tomography is a potential biomarker for AD and PD, and if these pathologies are suspected early, and if these pathologies are suspected early, it could be requested as diagnostic support.