Open AccessCase report on kawasaki patient with immunoglobulin non-response successfully treated by infliximab
Author(s) -
Đặng Thị Hải Vân,
Phan Thi Thuy Ngan,
Đỗ Minh Thùy,
Cao Việt Tùng
Publication year - 2018
Publication title -
tạp chí nghiên cứu và thực hành nhi khoa/journal of pediatric research and practice
Language(s) - English
Resource type - Journals
eISSN - 2734-9179
pISSN - 2615-9198
DOI - 10.47973/jprp.v2i5.150
Subject(s) - kawasaki disease , medicine , infliximab , aspirin , systemic vasculitis , vasculitis , pathophysiology , etiology , disease , limiting , presentation (obstetrics) , antibody , immunology , surgery , artery , mechanical engineering , engineering
Background: Kawasaki disease KD is self-limiting acute multi-systemic vasculitis of unknown etiology.Current treatment recommendations for acute KD include IVIG and aspirin, but there are no evidence-basedguidelines for children who do not respond to IVIG treatment. Over the past few years, increasing knowledge ofthe pathophysiology of KD has resulted in the identification of key inflammation mediators and the use ofbiologic pathway targeting agents such as TNF and IL-1 inhibitors for children with IVIG-resistant disease.Case presentation: A 11-month-old girl was diagnosed with typical KD and treated with 3 IVIG and 1corticoid therapy, but the coronary arteries continued to dilate. After that, the patient was treated successfullywith Infliximab.