Open AccessFormulation and Invitro evaluation of immediate release tablets containing febuxostat
Author(s) -
Srikumar Billa,
Saibabu Ch,
T. Malyadri
Publication year - 2021
Publication title -
international journal of pharmaceutics and drug analysis
Language(s) - English
Resource type - Journals
ISSN - 2348-8948
DOI - 10.47957/ijpda.v9i2.466
Subject(s) - febuxostat , croscarmellose sodium , granulation , excipient , compression (physics) , chemistry , materials science , chromatography , dosage form , composite material , magnesium stearate , uric acid , biochemistry , hyperuricemia
In the present research work, Febuxostat Immediate Release Tablet was prepared by direct compression method using varying concentrations of Lycoat, Crospovidone& Croscarmellose sodium as disintegrants. The formulations prepared were evaluated for precompression& post-compression parameters. From the drug excipient compatibility studies, we observe that there are no interactions between the pure drug (Febuxostat) and optimized formulation (Febuxostat+ excipients) which indicates there are no physical changes. Post compression parameters were found to be within the limits. Among the formulation prepared the tablet containing 12mg of CCS shows 98.13% of the drug release within 45 min & follows first-order kinetics.