Formulation and Invitro evaluation of immediate release tablets containing febuxostat | Zendy

Srikumar Billa | Zendy; Saibabu Ch | Zendy; T. Malyadri | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Formulation and Invitro evaluation of immediate release tablets containing febuxostat

Author(s) -

Srikumar Billa,

Saibabu Ch,

T. Malyadri

Publication year - 2021

Publication title -

international journal of pharmaceutics and drug analysis

Language(s) - English

Resource type - Journals

ISSN - 2348-8948

DOI - 10.47957/ijpda.v9i2.466

Subject(s) - febuxostat , croscarmellose sodium , granulation , excipient , compression (physics) , chemistry , materials science , chromatography , dosage form , composite material , magnesium stearate , uric acid , biochemistry , hyperuricemia

In the present research work, Febuxostat Immediate Release Tablet was prepared by direct compression method using varying concentrations of Lycoat, Crospovidone& Croscarmellose sodium as disintegrants. The formulations prepared were evaluated for precompression& post-compression parameters. From the drug excipient compatibility studies, we observe that there are no interactions between the pure drug (Febuxostat) and optimized formulation (Febuxostat+ excipients) which indicates there are no physical changes. Post compression parameters were found to be within the limits. Among the formulation prepared the tablet containing 12mg of CCS shows 98.13% of the drug release within 45 min & follows first-order kinetics.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research