Open AccessPresent Tense: A Peculiar Case of Pemphigus Vulgaris Presenting with Tense Blisters during the COVID-19 Pandemic
Author(s) -
Dianne Katherine R. Salazar-Paras,
Mae N. Ramirez-Quizon
Publication year - 2021
Publication title -
acta medica philippina/acta medica philippina
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.128
H-Index - 4
eISSN - 2094-9278
pISSN - 0001-6071
DOI - 10.47895/amp.v55i5.2890
Subject(s) - pemphigus vulgaris , histopathology , pemphigoid , direct fluorescent antibody , dermatology , bullous pemphigoid , pemphigus , blisters , pathology , medicine , epidermis (zoology) , immunofluorescence , covid-19 , immunology , antibody , anatomy , disease , infectious disease (medical specialty)
Pemphigus vulgaris is an autoimmune bullous dermatosis presenting with flaccid blisters and erosions. The morphology of pemphigus reflects the more superficial intraepidermal level of split seen histologically in contrast with pemphigoid, where the level of split is deep below the epidermis. This is a case of a 58-year-old male clinically presenting with arcuate tense bullae, which are more characteristic of the pemphigoid group of disorders, which revealed an intraepidermal split and tombstoning pattern of the basal epidermis on histopathology. Direct immunofluorescence revealed intercellular IgG and C3 distribution. Although this patient presented clinically with tense bullae, the histopathology and direct immunofluorescence results were consistent with pemphigus vulgaris.