Open AccessArsenicosis Presenting with Cutaneous Squamous Cell Carcinoma: A Case Report
Author(s) -
Marie Len A. Camaclang,
Eileen Liesl A. Cubillan,
Claudine Yap-Silva
Publication year - 2019
Publication title -
acta medica philippina/acta medica philippina
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.128
H-Index - 4
eISSN - 2094-9278
pISSN - 0001-6071
DOI - 10.47895/amp.v53i2.208
Subject(s) - medicine , basal cell , dermatology , lesion , keratosis , pathology , skin cancer , cancer
A 29-year-old male with eleven-year history of hyperkeratotic papules and speckled pigmentation developed cutaneous squamous cell carcinoma. Arsenicosis was confirmed by elevated hair arsenic level, and histopathologic findings of arsenical keratosis and one lesion showing carcinoma-in-situ. Chronic arsenic exposure has been found to activate inflammatory and carcinogenic pathways leading to development of pre-malignant and malignant lesions. A multi-disciplinary approach involving healthcare specialists and environmentalists is crucial in source control and management of long-term complications.