Open AccessPreparation of Gefitinib Loaded Polycaprolactone Microcapsule For Controlled Release Drug Delivery System
Author(s) -
Priyangi Roy,
Purusattam Gartia,
Aritra Nayek,
Abhishek Samanta
Publication year - 2017
Publication title -
international journal of pharmacology and pharmaceutical technology
Language(s) - English
Resource type - Journals
ISSN - 2277-3436
DOI - 10.47893/ijppt.2017.1025
Subject(s) - polycaprolactone , drug , drug delivery , chromatography , particle size , dissolution , polymer , materials science , chemistry , dissolution testing , pharmacology , chemical engineering , nanotechnology , organic chemistry , medicine , ethyl cellulose , engineering
The aim of the study was to prepare gefitinib-loaded polycaprolactone microcapsules by simple conventional solvent evaporation method with a view to achieve controlled release of the drug following subcutaneous administration once in a week fortargeted therapeutic action especially locally. The microcapsules were prepared using different drug-polymer ratios (1:2, 1:4 and 1:6) and three different stabilizers/surfactants (0.25% w/v, 0.50% w/v and 0.75% w/v) concentrations in aqueous phase. Dependingupon the formulation variables, the highest drug entrapment efficiency and the lowest average particle size diameter of the microcapsules were found to be respectively 90.19±2.61 % and 201±3.05 µ. Comparison of Fourier Transform Infra Red spectra ofgefitinib, polycaprolactone, their physical mixture and the drug- loaded microcapsules showed the absence of drug -polymer interaction .The in-vitro dissolution study showed that the release of drug from the microcapsules was almost complete on day seventh and the drug release followed Higuchi model.