Open AccessApplication of ultra performance liquid chromatography- triple quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) for the determination of antibiotic residues in meat and fish
Author(s) -
Chinh Nguyen Van,
Tuyet Trang Dang,
Truc Kha Doan Thi,
Quynh Mai Cao Thi,
Thien Le Van,
Hoang Bui Huy,
Tu Lam Van
Publication year - 2019
Publication title -
kiểm nghiệm và an toàn thực phẩm/kiểm nghiệm và an toàn thực phẩm (online)
Language(s) - English
Resource type - Journals
eISSN - 2734-9152
pISSN - 2615-9252
DOI - 10.47866/2615-9252/vjfc.84
Subject(s) - chromatography , chemistry , mass spectrometry , residue (chemistry) , cefalexin , high performance liquid chromatography , ampicillin , quadrupole time of flight , antibiotics , liquid chromatography–mass spectrometry , tandem mass spectrometry , biochemistry
The residue of antibiotics in meat and meat products is one of the social problems for its effects and risks to human health, especially in the antibiotic resistance crisis. Nowadays, there are hundreds of drugs commercially available, with difference biochemical characteristics. Therefore, it is necessary to determine and monitor these residues in meat and meat products. The methods using liquid chromatography (LC) and ELISA are widely applied in numbers of laboratories to determine specified substances. In several laboratories, the state-of-the-art highresolution analytical technique, using Ultra Performance Liquid chromatography-triple quadrupole Time-of-flight mass spectrometry (UPLC-QTOF-MS), is applied to analyse the knowns and unknowns residues in food. In this study, we used this technique for screening the residue of antibiotics, banned substances (Sulfonamids, Quinolones, Tetracyclines, β-Agonists…) and other toxins in pork, chicken, beef and fish samples. Ninety-three randomly collected samples have been screened and residues of Amoxicillin, Cefalexin and Ampicillin have been detected in three of them.