Open AccessThe Effects of Honey Administration on Petrol-Induced Oxidative Stress and Hepatotoxicity in Sprague-Dawley Male Rats
Author(s) -
Murtala Bello Abubakar,
Boon Suen Ang
Publication year - 2020
Publication title -
annals of clinical and experimental medicine
Language(s) - English
Resource type - Journals
ISSN - 2714-4666
DOI - 10.47838/acem.26011977.11162020.asmeda.3.0
Subject(s) - oxidative stress , catalase , pantothenic acid , thiamine , pharmacology , ascorbic acid , pyridoxine , chemistry , nephrotoxicity , riboflavin , medicine , toxicology , food science , toxicity , biochemistry , biology
Background: Exposure to petrol is common among individuals working in oil refineries, oil fields, filling stations, automobile mechanical workshops. Exposure to petrol is associated with a number of health hazards including hepatotoxicity and oxidative stress. Honey is rich in many antioxidants such as catalase, flavonoids, thiamine, riboflavin, pyridoxine, pantothenic acid, ascorbic acid and nicotinic acid and was recently reported to reduce petrol-induced hepatotoxicity and nephrotoxicity. Materials and Methods: A total of 32 male Sprague-Dawley rats were randomly divided into four groups: control group (exposed to ambient air daily), petrol exposed group