Open AccessAVALIAÇÃO DO POTENCIAL TRIPANOCIDA DE DERIVADOS TIOSSEMICARBAZONAS: UMA REVISÃO
Author(s) -
Daniel Lopes Araújo,
José Eufrazino Júnior,
Vinicius Santos Silva,
Carla Franco Mendonça de Araújo,
Thaynara Hevellin Evangelista,
Hilary Hevellin Evangelista,
Geovana Maciel Lima,
Ana Karoline Maciel Lima,
Willian Moreira,
Antônio Antunes Neto,
Neusa Loíse Nunes Albuquerque,
Graziele Ferreira Nunes,
Josué Brito Gondim,
Emanuel Osvaldo de Sousa,
Bruno Abílio da Silva Machado
Publication year - 2021
Publication title -
recima21
Language(s) - English
Resource type - Journals
ISSN - 2675-6218
DOI - 10.47820/recima21.v2i9.658
Subject(s) - chagas disease , trypanosoma cruzi , antiprotozoal , scielo , benznidazole , neglected tropical diseases , tropical disease , medicine , traditional medicine , disease , pharmacology , biology , medline , immunology , computer science , parasite hosting , biochemistry , world wide web , in vitro
Neglected diseases are a group of communicable diseases that mainly affect tropical regions in developing countries. Among this group of diseases is Chagas disease, which has been classified among the six most important parasitic diseases in the world, and it is estimated that more than one billion people are at risk in countries that are considered endemic. The aim of this study is to conduct a literature review on the trypanocidal activity of thiosemicarbazone derivatives. The study is a review research that used 31 articles to highlight the scientific findings on the trypanocidal activity of the derivatives in question. Articles were included in the time estimate between 2010 - 2021 (last 12 years). The search and selection of the reference studies was performed in Scielo, Science Direct, PubMed and Google Academic databases. The literature highlights that thiosemicarbazones are considered privileged compounds with a wide scientific interest due to their diverse chemical and biological properties, such as: antitumor, antibacterial, antiviral, antiprotozoal, and anti-chagasic. The studies presented here, which demonstrate the investigations of compounds of this class and their derivatives, are an important step towards the conception of therapeutic methods against Trypanosoma cruzi. New studies are necessary to elucidate in an even more specific way the effects of these derivatives in vivo, in order to obtain an alternative pharmacological therapy for Chagas disease.