Open AccessDietary restriction in multiple sclerosis: evidence from preclinical and clinical studies
Author(s) -
Eileen Liao,
Laura Ghezzi,
Laura Piccio
Publication year - 2022
Publication title -
advances in clinical neuroscience and rehabilitation
Language(s) - English
Resource type - Journals
eISSN - 2397-267X
pISSN - 1473-9348
DOI - 10.47795/mcln8939
Subject(s) - multiple sclerosis , neuroinflammation , psychological intervention , medicine , gut microbiome , disease , microbiome , animal studies , neuroscience , bioinformatics , psychology , immunology , gut flora , biology , psychiatry
Dietary restriction (DR) interventions, which encompass both chronic and intermittent reductions in energy intake, are emerging as potential therapeutic approaches for dampening neuroinflammation and demyelination in multiple sclerosis (MS). Mechanisms mediating the beneficial effects of DR include the regulation of pro- and anti-inflammatory signalling molecules and gut microbiome remodelling. This article summarises the preclinical evidence supporting the role of DR in attenuating disease in animal models of MS and the developing clinical evidence indicating the safety and feasibility of such DR interventions in people with MS (pwMS).